摘要
目的 研究皂帽花(Dasymaschalon trichophorum Mer)的化学成分,以期得到有活性的先导化合物。方法 采用硅胶柱色谱、凝胶柱色谱、高效液相色谱等方法进行分离纯化,通过理化性质和波谱数据分析鉴定化合物的结构。结果 从皂帽花的石油醚层、三氯甲烷层和乙酸乙酯层萃取物中共分离得到10个化合物,分别鉴定为5-methoxydasytrichone (1)、(2R,3R)-3,5,7,3′,4′-五羟基双氢黄烷 (2)、dasytrichone (3)、3,4,5-trimethoxyphenol-β-D-glucopyranoside (4)、N-反式-咖啡酰基对羟基苯乙胺(5)、1′,4-dihydroxy-3,3′,5′-trimethoxy-8,4′-oxyneoligna-7,9-diol (6)、白藜芦醇 (7)、柚皮素(8)、二氢山柰酚 (9)、圣草酚 (10)。结论 除化合物3外,其余9个化合物为首次从皂帽花属植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of Dasymaschalon trichophorum Mer. METHODS The chemical constituents were isolated and purified by silica gel,Sephadex LH-20,and recrystallization. Their structures were elucidated by spectral analysis and physicochemical properties. RESULTS Ten compounds were obtained from petroleum ether fraction,ethyl acetate fraction and chloroform fraction of water extraction of Dasymaschalon trichophorum Mer. They were identified as 5-methoxydasytrichone(1),(2R,3R)-3,5,7,3′,4′-pentahydroxyflavane(2),dasytrichone(3),3,4,5-trimethoxyphenol-β-D-glucopyranoside(4), N-trans-caffeoyltyramine(5),1′,4-dihydroxy-3,3′,5′-trimethoxy-8,4′-oxyneoligna-7,9-diol(6),resveratrol(7), naringetol(8),dihydrokaempferol(9) and eriodictyol(10). CONCLUSION Compounds 1,2,4,5,6,7,8,9 and 10 are isolated from Dasymaschalon trichophorum Mer for the first time.
关键词
皂帽花 /
5-methoxydasytrichone /
(2R /
3R)-3 /
5 /
7 /
3′ /
4′-五羟基双氢黄烷 /
黄酮 /
结构鉴定
{{custom_keyword}} /
Key words
Dasymaschalon trichophorum Mer /
5-methoxydasytrichone /
(2R,3R)-3,5,7,3′,4′-pentahydroxyflavane /
flavonoids /
structure identification
{{custom_keyword}} /
周晓磊,,史宁,白皎,吴久鸿*.
皂帽花的化学成分研究[J]. 中国药学杂志, 2013, 48(11): 863-866 https://doi.org/10.11669/cpj.2013.11.007
ZHOU Xiao-lei,,SHI Ning,BAI Jiao,WU Jiu-hong*.
Chemical Constituents of Rhizome of Dasymaschalon trichophorum Mer[J]. Chinese Pharmaceutical Journal, 2013, 48(11): 863-866 https://doi.org/10.11669/cpj.2013.11.007
中图分类号：
R284
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] JIANG Y, LI P T. Flora of China(中国植物志) . Beijing:Science Press, 1979:164. [2] SADRI A S. Two new special flavones from Uvaria accuminata . Nat Prod Res, 2011, 25(10):987-994. [3] HOU A J, LIU Y Z, YANG H, et al. Hydrolyzable tannins and related polyphenols from Eucalyptus globulus . J Asian Nat Prod Res, 2000, 2(2):205-212. [4] LIU Y L, HO D K, CASSADY J M, et al. Dasytrichone, a novel flavone from Dasymaschalon trichophorum with cancer chemopreventive potential . Nat Prod Res, 1992, 1(3):161-165. [5] SAUO R, NONAKA G I,NISHIOKA I. Phenolic glucosides gallates from Mallotus japonicus. Phytochemistry, 1989, 28(9):2443-2446. [6] FUKUDA N, YONEMITSU M,KIMURA T. Studies on the constituents of the stems of tinospora tuberculata beumee . Chem Pharm Bull, 1983, 31(1):156-161. [7] XIONG L, ZHU C G, LI Y, et al. Lignans and neoligans from Sinocalamus affinis and their absolute configurations . J Nat Prod, 2011, 74(5):1188-1200. [8] CHEN P, YANG J S. Chemical constituents from the Caesalpinia millettii. Chin Pharm J(中国药学杂志), 2008, 43(24):1852-1854. [9] REN D M, LOU H X, JI M. Studies on constituents of Dracocephalum rupestra. Chin Pharm J(中国药学杂志), 2005, 40(22):1695-1696. TAN Y X, LIU C, CHEN R Y. Phenolic constituents from stem bark of Morus wittiorum and their anti-inflammation and cytotoxicity . China J Chin Mater Med(中国中药杂志), 2010, 35(20):2700-2703. WANG X G, SHEN L T, ZENG Y Y, et al. Flavonoids from Ficus sarmentosa var. henryi . Chin Tradit Herb Drugs(中草药), 2010, 41(4):526-529.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家自然科学基金资助项目(81072546);全军“十一五”杰出人才基金资助项目(06J001)
{{custom_fund}}
PDF(484 KB)
